吴文武 | 生物信息学博士、三级教授、博士生导师

研究团队主要基于计算机科学、基因组学、进化生物学、生态学等多学科交叉手段，研究不同植物类群的趋同或平行进化（我更喜欢使用“进化”二字，虽不如“演化”精准，但其更富有情感和动力）。近五年来，以通讯作者（含共同）在Current Biology,Cell Reports,Mol Biol Evol,Plant Cell,Plant Commun(2022, 2023, 2025),J Integr Plant Biol,New Phytol(2024, 2026),J Adv Res(2024, 2026),Plant J等国际主流期刊发表科研论文十余篇。

核心研究理念

区别于侧重“辐射进化与多样性”的传统视角，我们聚焦于物种在等效环境压力下的相似进化策略，旨在解答生命科学中的一个核心问题：生物进化的方向究竟是否具有再现性、重复性与可预测性？

 主要研究方向

1.古气候剧变期被子植物的生存之道。“以史为鉴，可知兴替”，地球曾多次经历生物大爆发与大灭绝。通过深度解析植物基因组，追寻自然选择的进化印记，鉴定在全球古气候温度剧变时期起关键作用的基因群。该方向研究有助于理解植物的进化历史，并为应对当前全球暖化提供科学理论依据。

2.不同特殊植物类型的各自趋同之谜。被子植物在水生、寄生、附生、腐生及潮间带等极端或特殊生境中，面对相似的环境压力时常展现出惊人的相似性。通过比较基因组和生态地理特征，揭示其趋同进化机理。该方向研究有助于理解植物在特殊生境下的生存逻辑，为农业、生态保护等提供理论基础。

3.油料作物高油含量的殊途同归之谜。草本与木本植物虽形态迥异，却皆存在富集油脂之异能。当前主流研究各自为战，强调物种特异性、各自优越性。我们希望揭示草本与木本植物富集油脂的共性作用机制，以“它山之石，可以攻玉”，为分子育种提供通用基因资源，赋能产业创新。

4.探索未知。在这里，对于特别优秀的学生，可以自己定方向：****趋同进化研究。（期待与充满好奇心的你同行；欢迎对本课题组感兴趣的硕博研究生及博士后来信联系）

学习与工作经历

2017/01—至今 浙江农林大学教授

2016/05—2017/01浙江农林大学副研

2014/11—2016/05 中科院上海植物逆境研究中心副研

2012/10—2014/10 中科院上海生科院营养所博士后

2010/10—2011/09 中科院北京植物研究所联合培养

2007/09—2012/09 西北农林科技大学博士

教学工作

生物信息学理论与实践、测序原理及其分析、新生研讨课等

科研项目

先后主持国家自然科学基金项目3项、博士后项目2项。

主要作者研究论文（2022—至今，†第一作者，*通讯作者）

1. Jia Y*, Zhang Y*, Ye X*, Guo L, Li H, Guo Y, Wang J, Wang S, andWu W#. Evolutionary and functional analyses in angiosperms reveal a conserved cold-responsive WRKY33-NAC032 module.New Phytologist2026; doi: 10.1111/nph.71013

2. Wang S*, Meng Z*, Liu H*, Deng D, Du Y, Guo L, Cai B, Yang H, Li C, Zhou Y, Shen Y, Ye X, Wu W#, and Li Y#. (2026). MAC5A dual-functionally regulates cold responses at both transcriptional and post-transcriptional levels.J Adv Res, doi: 10.1016/j.jare.2026.01.015.

3. Guo L, Yin L, Sun C, Zhao K, Zhao H, Bai S, Li Y, andWu W#. Gradual genomic streamlining and convergent adaptation during terrestrial-to-aquatic transitions in angiosperms.Current Biology2025;35(19):4595-605.

4. Wang S*, Li J*, Yu P*, Guo L, Zhou J, Yang J#, andWu W#. Convergent evolution in angiosperms adapted to cold climates.Plant Communications2025;6(2):101258.

5. Zhuang H*, Lin E*, Xie J*, Jiang M, Ni F, Shi S, Liu M, Miao S, Wei M, Li C, Liu J, Liu X, Hu X,Wu W#, Salojarvi J#, Huang H#. InDel variation and contraction of the C-repeat binding factor family contribute to cold sensitivity inBetula fujianensis.Plant Cell2025.37(10):koaf216

6. Deng D, Guo Y, Guo L, Li C, Nie Y, Wang S, andWu W*. (2024). Functional divergence in orthologous transcription factors: insights from AtCBF2/3/1 and OsDREB1C.Mol Biol Evol41, msae089.

7. Du Y, Cao L, Wang S, Guo L, Tan L, Liu H, Feng Y*, andWu W*. (2024). Differences in alternative splicing and their potential underlying factors between animals and plants.J Adv Res64, 83-98.

8. Guo L, Wang S, Jiao X, Ye X, Deng D, Liu H, Li Y*, Van de Peer Y*, andWu W*. (2024). Convergent and/or parallel evolution of RNA-binding proteins in angiosperms after polyploidization.New Phytol242, 1377-1393.

9.Wu W*†, Guo L†, Yin L, Cai B, Li J, Li X, Yang J, Zhou H, Tao Z*, and Li Y*. (2024). Genomic convergence in terrestrial root plants through tandem duplication in response to soil microbial pressures.Cell Rep43, 114961.

10. Wang S, Shen Y, Deng D, Guo L, Zhang Y, Nie Y, Du Y, Zhao X, Ye X, Huang J, Huang H*, Zhu J-K*, andWu W*. Orthogroup and phylotranscriptomic analyses identify transcription factors involved in plant cold response: a case study ofArabidopsisBBX29.Plant Commun2023. 100684.

11. Guo L, Xu Z, Wang S, Nie Y, Ye X, Jin X*, Zhu J*, andWu W*. Integrative multi-omics analysis of three early diverged rosid species reveals an ancient hierarchical cold-responsive regulatory network.Physiol Plant.2023.175(2):e13892

12. Wang S, Zhang Y, Ye X, Shen Y, Liu H, Zhao X, Guo L, Cao L, Du Y, andWu W*. A phylotranscriptomic dataset of angiosperm species under cold stress.Sci Data2023. 10,399.

13. Guo L, Wang S, Nie Y, Shen Y, Ye X,Wu W*. Convergent evolution of AP2/ERF III and IX subfamilies recurrently through polyploidization and tandem duplication in eudicot adaptation to paleoenvironmental changes.Plant Commun.2022.3(6):100420.

14. Nie Y, Guo L, Cui F, Shen Y, Ye X, Deng D, Wang S*, Zhu J*,Wu W*. Innovations and Stepwise Evolution of CBFs/DREB1s and Their Regulatory Networks in Angiosperms.J Integr Plant Biol2022.64(11):2111-2125.

15. Ye X, Wang S, Zhao X, Gao N, Wang Y, Yang Y, Wu E, Jiang C, Cheng Y,Wu W*, Liu S*. Role of lncRNAs in cis- and trans-regulatory responses to salt inPopulus trichocarpa.Plant Journal2022. 110(4): 978-993.

16. Cui F†, Li X†,Wu W†, Luo W, Wu Y, Brosche M, Overmyer K. Ectopic expression of BOTRYTIS SUSCEPTIBLE1 reveals its function as a positive regulator of wound-induced cell death and plant susceptibility to Botrytis.Plant Cell2022. 10(34): 4105-4116

17. Wang S, Shen Y, Guo L, Tan L, Ye X, Yang Y, Zhao X, Nie Y, Deng D, Liu S*,Wu W*. Innovation and Emerging Roles ofPopulus trichocarpaTEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Abiotic Stresses by Whole-Genome Duplication.Front Plant Sci2022, 13: 850064.

2020年及以前（†第一作者，*通讯作者）

18. Ye X, Zhao X, Sun Y, Zhang M, Feng S, Zhou A,Wu W*, Ma S*, Liu S*. The underlying molecular conservation and diversification of dioecious flower and leaf buds provide insights into the development, dormancy breaking, flowering, and sex association of willows. Plant Physiol Biochem 2021, 167: 651-664.

19. Zhao X, Tan L, Wang S, Shen Y, Guo L, Ye X, Liu S, Feng Y*,Wu W*. The SR Splicing Factors: Providing Perspectives on Their Evolution, Expression, Alternative Splicing, and Function inPopulus trichocarpa. Int J Mol Sci 2021, 22(21): 11369.

20. Zhang C, Shen L, Yuan W, Liu Y, Guo R, Luo Y, Zhan Z, Xie Z, Wu G,Wu W*, Feng Y*. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.Commun Biol2020, 3(1): 210.

21. 杨艳梅,赵喜娟,聂语琪,柳参奎,吴文武*.草本拟南芥和木本毛果杨在冷胁迫下的研究进展.分子植物育种2020, 18(17): 5755-5764.

22.Wu W*†, Zong J†, Wei N, Cheng J, Zhou X, Cheng Y, Chen D, Guo Q, Zhang B, Feng Y*. CASH: a constructing comprehensive splice site method for detecting alternative splicing events.Brief Bioinform2018, 19(5): 905-917.

23. He L†,Wu W†, Zinta G, Yang L, Wang D, Liu R, Zhang H, Zheng Z, Huang H, Zhang Q, Zhu JK. A naturally occurring epiallele associates with leaf senescence and local climate adaptation inArabidopsisaccessions.Nat Commun2018, 9(1): 460.

24. Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z,Wu W*, Feng Y*. SRSF2 regulates alternative splicing to drive hepatocellular carcinoma development.Cancer Res2017, 77(5): 1168-1178.

25. Cheng J†, Xu Z†,Wu W†, Zhao L, Li X, Liu Y, Tao S. Training set selection for the prediction of essential genes.PLoS One2014, 9(1): e86805.

26. Zhou X†,Wu W†, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H, Feng Y. Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.Nucleic Acids Res2014, 42(6): 4019-4030.

27. Cheng J,Wu W†, Zhang Y, Li X, Jiang X, Wei G, Tao S. A new computational strategy for predicting essential genes.BMC Genomics2013, 14: 910.

28.Wu W, Huang X, Cheng J, Li Z, de Folter S, Huang Z, Jiang X, Pang H, Tao S. Conservation and Evolution in and among SRF- and MEF2-Type MADS Domains and Their Binding Sites.Mol Biol Evol2011, 28(1): 501-511.

29.Wu W, de Folter S, Shen X, Zhang W, Tao S. Vertebrate Paralogous MEF2 Genes: Origin, Conservation, and Evolution.PLoS One2011, 6(3): e17334.

30.Wu W, Shen X, Tao S. Characteristics of the CArG-SRF binding context in mammalian genomes.Mamm Genome2010, 21(1): 104-113.

联系方式

通讯地址：浙江省杭州市临安区武肃街666号林业与生物技术学院学6-300室

邮 编：311300

邮 箱：wwwu@zafu.edu.cn