吴文武 生物信息学博士、三级教授、博士生导师。主要结合计算机科学、基因组学、进化分子生物学、生态学等多学科的技术手段，研究不同植物类群在相似生境下的趋同或平行进化（我更喜欢使用“进化”二字，虽然不如“演化”精准，但其更富有情感和动力）。近年来，以第一或通讯作者（含共同）在Mol Bio Evol, Cell Rep, Plant Cell, New Phytol,Plant Commun (2022, 2023), J Integr Plant Biol, J Adv Res,Plant J等期刊发表论文十余篇。

研究方向

1.全球古气候温度剧变时期林草植物的生存之道。“以史为鉴，可知兴替”，地球在其漫长的历史中，经历了多次生命大爆发和大灭绝；通过对林草基因组的深入分析，探寻自然选择进化的痕迹，鉴定在全球古气候温度剧变时期起关键作用的基因群。该方向研究有助于理解植物的进化历史，并为应对当前的气候变化提供科学基础。

（实际上就是想知道为啥有的植物在生物大灭绝时期能存活下来，是躲在哪个旮旯，还是拥有特殊的生存能力或“超级基因”？）

2.林草生态地理及其基因组的趋同进化：被子植物在不同生境下（如水生、盐生、寄生、附生、腐生、潮间带等）展现出进化的多样性，但在面对相似环境压力下又进化出惊人的相似性，可谓“万殊归一理”。通过比较不同类群植物的基因组和生态地理特征，揭示其趋同进化过程。该方向研究有助于理解植物在特殊生境下的底层生存逻辑，并为农业、生态保护等提供一些理论基础。

（实际上就是想知道被子植物在面对相似生境下，其演化是否具有方向性和可预测性？）

学习与工作经历

2017/01—至今 浙江农林大学 教授

2016/05—2017/01浙江农林大学副研

2014/11—2016/05 中科院上海植物逆境研究中心副研

2012/10—2014/10 中科院上海生科院营养所博士后

2010/10—2011/09 中科院北京植物研究所联合培养

2007/09—2012/09 西北农林科技大学博士

教学工作

生物信息学理论与实践、测序原理及其分析、新生研讨课等

科研项目

先后主持国家自然科学基金项目3项、博士后项目2项。

主要作者研究论文（2021-2024年，†第一作者，*通讯作者）

1.Deng D, Guo Y, Guo L, Li C, Nie Y, Wang S, andWu W*. (2024). Functional divergence in orthologous transcription factors: insights from AtCBF2/3/1 and OsDREB1C. Mol Biol Evol 41, msae089.

2.Du Y, Cao L, Wang S, Guo L, Tan L, Liu H, Feng Y*, andWu W*. (2024). Differences in alternative splicing and their potential underlying factors between animals and plants. J Adv Res 64, 83-98.

3.Guo L, Wang S, Jiao X, Ye X, Deng D, Liu H, Li Y*, Van de Peer Y*, andWu W*. (2024). Convergent and/or parallel evolution of RNA-binding proteins in angiosperms after polyploidization. New Phytol 242, 1377-1393.

4.Wu W*†, Guo L†, Yin L, Cai B, Li J, Li X, Yang J, Zhou H, Tao Z*, and Li Y*. (2024). Genomic convergence in terrestrial root plants through tandem duplication in response to soil microbial pressures. Cell Rep43, 114961.

5.Wang S, Shen Y, Deng D, Guo L, Zhang Y, Nie Y, Du Y, Zhao X, Ye X, Huang J, Huang H*, Zhu J-K*, andWu W*. Orthogroup and phylotranscriptomic analyses identify transcription factors involved in plant cold response: a case study ofArabidopsis BBX29. Plant Commun 2023. 100684.

6.Guo L, Xu Z, Wang S, Nie Y, Ye X, Jin X*, Zhu J*, andWu W*. Integrative multi-omics analysis of three early diverged rosid species reveals an ancient hierarchical cold-responsive regulatory network. Physiol Plant. 2023. 175(2):e13892

7.Wang S, Zhang Y, Ye X, Shen Y, Liu H, Zhao X, Guo L, Cao L, Du Y, andWu W*. A phylotranscriptomic dataset of angiosperm species under cold stress. Sci Data 2023. 10, 399.

8.Guo L, Wang S, Nie Y, Shen Y, Ye X,Wu W*. Convergent evolution of AP2/ERF III and IX subfamilies recurrently through polyploidization and tandem duplication in eudicot adaptation to paleoenvironmental changes. Plant Commun. 2022. 3(6):100420.

9.Nie Y, Guo L, Cui F, Shen Y, Ye X, Deng D, Wang S*, Zhu J*,Wu W*. Innovations and Stepwise Evolution of CBFs/DREB1s and Their Regulatory Networks in Angiosperms. J Integr Plant Biol 2022. 64(11):2111-2125.

10.Ye X, Wang S, Zhao X, Gao N, Wang Y, Yang Y, Wu E, Jiang C, Cheng Y,Wu W*, Liu S*. Role of lncRNAs in cis- and trans-regulatory responses to salt inPopulus trichocarpa. Plant Journal 2022.110(4): 978-993.

11.Cui F†, Li X†,Wu W†, Luo W, Wu Y, Brosche M, Overmyer K. Ectopic expression of BOTRYTIS SUSCEPTIBLE1 reveals its function as a positive regulator of wound-induced cell death and plant susceptibility to Botrytis. Plant Cell 2022. 10(34): 4105-4116

12.Wang S, Shen Y, Guo L, Tan L, Ye X, Yang Y, Zhao X, Nie Y, Deng D, Liu S*,Wu W*. Innovation and Emerging Roles ofPopulus trichocarpa TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Abiotic Stresses by Whole-Genome Duplication. Front Plant Sci 2022, 13: 850064.

13.Ye X, Zhao X, Sun Y, Zhang M, Feng S, Zhou A,Wu W*, Ma S*, Liu S*. The underlying molecular conservation and diversification of dioecious flower and leaf buds provide insights into the development, dormancy breaking, flowering, and sex association of willows. Plant Physiol Biochem 2021, 167: 651-664.

14.Zhao X, Tan L, Wang S, Shen Y, Guo L, Ye X, Liu S, Feng Y*,Wu W*. The SR Splicing Factors: Providing Perspectives on Their Evolution, Expression, Alternative Splicing, and Function in Populus trichocarpa. Int J Mol Sci 2021, 22(21): 11369.

2020年及以前（†第一作者，*通讯作者）

1.Zhang C, Shen L, Yuan W, Liu Y, Guo R, Luo Y, Zhan Z, Xie Z, Wu G,Wu W*, Feng Y*. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.Commun Biol 2020, 3(1): 210.

2.杨艳梅,赵喜娟,聂语琪,柳参奎,吴文武*.草本拟南芥和木本毛果杨在冷胁迫下的研究进展.分子植物育种 2020, 18(17): 5755-5764.

3.Wu W*†, Zong J†, Wei N, Cheng J, Zhou X, Cheng Y, Chen D, Guo Q, Zhang B, Feng Y*. CASH: a constructing comprehensive splice site method for detecting alternative splicing events.Brief Bioinform 2018, 19(5): 905-917.

4.He L†,Wu W†, Zinta G, Yang L, Wang D, Liu R, Zhang H, Zheng Z, Huang H, Zhang Q, Zhu JK. A naturally occurring epiallele associates with leaf senescence and local climate adaptation inArabidopsis accessions.Nat Commun 2018, 9(1): 460.

5.Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z,Wu W*, Feng Y*. SRSF2 regulates alternative splicing to drive hepatocellular carcinoma development.Cancer Res 2017, 77(5): 1168-1178.

6.Cheng J†, Xu Z†,Wu W†, Zhao L, Li X, Liu Y, Tao S. Training set selection for the prediction of essential genes.PLoS One 2014, 9(1): e86805.

7.Zhou X†,Wu W†, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H, Feng Y. Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.Nucleic Acids Res 2014, 42(6): 4019-4030.

8.Cheng J,Wu W†, Zhang Y, Li X, Jiang X, Wei G, Tao S. A new computational strategy for predicting essential genes.BMC Genomics 2013, 14: 910.

9.Wu W, Huang X, Cheng J, Li Z, de Folter S, Huang Z, Jiang X, Pang H, Tao S. Conservation and Evolution in and among SRF- and MEF2-Type MADS Domains and Their Binding Sites.Mol Biol Evol 2011, 28(1): 501-511.

10.Wu W, de Folter S, Shen X, Zhang W, Tao S. Vertebrate Paralogous MEF2 Genes: Origin, Conservation, and Evolution.PLoS One 2011, 6(3): e17334.

11.Wu W, Shen X, Tao S. Characteristics of the CArG-SRF binding context in mammalian genomes.Mamm Genome 2010, 21(1): 104-113.

联系方式

通讯地址：浙江省杭州市临安区武肃街666号智能实验楼S204

邮 编：311300

电 话：0571-63801232

邮 箱：wwwu@zafu.edu.cn